Research article in Nature Communications
In our recent article published in Nature Communications entitled: "Structural basis of the gating mechanism...
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Welcome to the Pliotas Group research website
Mechanosensation is the ability of ion channels to sense and respond to tension changes within membranes by opening their pores, through which ions flow.
In our lab we investigate the molecular basis of mechanosensation and its role in the regulation of ion channels and other membrane proteins, such as ion pumps and membrane transporters.
The main methods we employ to structurally investigate mechanosensitive ion channels are Electron Paramagnetic Resonance (EPR) spectroscopy, Pulsed ELectron-electron DOuble Resonance (PELDOR), also known as Double Electron-Electron Resonance (DEER) spectroscopy and Cryo Electron Microscopy (cryoEM). We functionally characterise these systems by employing single molecule electrophysiology methods.
